2.1.3. Ultraviolet ray lamps for analytical purposes

基本信息

• 标准
  欧洲药典
• 版本
  EP8.0
• 来源
  VOLUME 1
• 分类
  GENERAL CHAPTERS
• 页码
  15

EUROPEAN PHARMACOPOEIA 8.02.1.3. Ultraviolet ray lamps for analytical purposes 2.1. APPARATUS 01/2008:20101 2.1.1. DROPPERS The term ‘drops’ means standard drops delivered from a standard dropper as described below. Standard droppers (Figure 2.1.1-1) are constructed of practically colourless glass. The lower extremity has a circular orifice in a flat surface at right angles to the axis. Figure 2.1.1.-1. –Standard dropper Dimensions in millimetres Other droppers may be used provided they comply with the following test. 20 drops ofwater Rat 20 ± 1 °C flowing freely from the dropper held in the vertical position at a constant rate of 1 drop per second weighs 1000 ± 50 mg. The dropper must be carefully cleaned before use. Carry out 3 determinations on any given dropper. No result may deviate by more than 5 per cent from the mean of the 3 determinations. 01/2008:20102 2.1.2. COMPARATIVE TABLE OF POROSITY OF SINTERED-GLASS FILTERS (1) Table 2.1.2.-1 Porosity number (Ph. Eur.) (2) Maximum diameter of pores in micrometres Germany France United Kingdom 1.6 less than 1.65f –– – 1-2.5 5 – 5 4 1.6 - 4 ––– – 4-6 – 5 – 104 - 10 4f – 4 1610 - 16 44 – 4016 - 40333 – 40 - 50 –– 2 10040 - 10022 – – 100 - 120 –– 1 160100 - 16011 – – 150 - 20000 – 250160 - 250 ––– – 200 - 500 – 00 – Special Uses Diameters in micrometres <2.5 Bacteriological filtration 4-10 Ultra-fine filtration, separation of micro-organisms of large diameter 10 - 40 Analytical filtration, very fine filtration of mercury, very fine dispersion of gases 40 - 100 Fine filtration, filtration of mercury, fine dispersion of gases 100 - 160 Filtration of coarse materials, dispersion and washing of gases, support for other filter materials 160 - 500 Filtration of very coarse materials, dispersion and washing of gases. 01/2008:20103 2.1.3. ULTRAVIOLET RAY LAMPS FOR ANALYTICAL PURPOSES Mercury vapour in quartz lamps is used as the source of ultraviolet light. A suitable filter may be fitted to eliminate the visible part of the spectrum emitted by the lamp. When the Pharmacopoeia prescribes in a test the use of ultraviolet light of wavelength 254 nm or 365 nm, an instrument consisting of a mercury vapour lamp and a filter which gives an emission band with maximum intensity at about 254 nm or 365 nm is used. The lamp used should be capable of revealing without doubt a standard spot of sodium salicylate with a diameter of about 5 mm on a support ofsilica gel G R,thespotbeing examined while in a position normal to the radiation. For this purpose apply 5 μL of a 0.4 g/L solution ofsodium salicylate Rinalcohol R (3) for lamps of maximum output at 254nmand5μLofa2g/Lsolutioninalcohol R (3) for lamps of maximumoutputat365nm.Thedistancebetweenthelamp and the chromatographic plate under examination used in a pharmacopoeial test should never exceed the distance used to carry out the above test. (1) The given limits are only approximate. (2) The European Pharmacopoeia has adopted the system proposed by the International Organization for Standardization (ISO). (3) Thealcohol Rused must be free from fluorescence. General Notices (1) apply to all monographs and other texts15 2.1.4. SievesEUROPEAN PHARMACOPOEIA 8.0 01/2008:20104 2.1.4. SIEVES Sieves are constructed of suitable materials with square meshes. For purposes other than analytical procedures, sieves with circular meshes may be used, the internal diameters of which are 1.25 times the aperture of the square mesh of the corresponding sieve size. There must be no reaction between thematerialofthesieveandthesubstancebeingsifted. Degree of comminution is prescribed in the monograph using the sieve number, which is the size of the mesh in micrometres,giveninparenthesisafterthenameofthe substance(Table2.1.4.-1). Maximum tolerance (4) for an aperture (+X): no aperture size shallexceedthenominalsizebymorethanX,where: w=widthofaperture. Tolerance for mean aperture (±Y): the average aperture size shallnotdepartfromthenominalsizebymorethan±Y, where: Intermediary tolerance (+Z):notmorethan6percentofthe total number of apertures shall have sizes between “nominal +X”and“nominal+Z”, w h e r e : Wire diameterd: the wire diameters given in Table 2.1.4.-1 apply to woven metal wire cloth mounted in a frame. The nominal sizes of the wire diameters may depart from these values within the limitsd max andd min .Thelimitsdefinea permissible range of choice ± 15 per cent of the recommended nominal dimensions. The wires in a test sieve shall be of a similar diameter in warp and weft directions. Table 2.1.4.-1 (values in micrometers) Tolerances for aperturesWire diameters Sieve numbers (Nominal dimensions of apertures) Maximum tolerance for an aperture Tolerance for mean aperture Intermediary tolerance Recommended nominal dimensions Admissible limits +X±Y +Z dd max d min 11 200770350560250029002100 8000600250430200023001700 5600470180320160019001300 4000370130250140017001200 28002909019011201300950 2000230701509001040770 140018050110710820600 10001403090560640480 7101122569450520380 5008918 54 315360270 355721343224260190 250589.934160190130 180 47 7.627125150106 125385.82290104 77 90324.6186372 54 63263.715 45 5238 45 223.113323727 38 ––– 303524 (4) See the International Standard ISO 3310/1 (1975). 16See the information section on general monographs (cover pages)

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